Endocrine Abstracts

Dependence receptors are receptors that display two totally different signal transductions depending on ligand availability. If in the presence of ligand, these receptors transduce a positive signal leading to differentiation/proliferation/migration, in the absence of ligand these receptors induce an active process of cell death. Thus, such receptors create cellular states of dependence on their respective ligands by inducing apoptosis when unoccupied by ligand. This growing f...